The Byzantine Empire is the term conventionally used to describe the Eastern part of the Roman Empire still alive during the Middle Ages, with its capital in Constantinople. The starting date of the Byzantine period is usually placed during the reign of Diocletian (284-305), due to the administrative reforms he introduced, dividing the empire into a pars Orientis and a pars Occidentis. Others place it during the reign of Theodosius I (379-395), with the division of the empire into Western and Eastern halves. Others place it yet further in 476, when the last western emperor, Romulus Augustus, was forced to abdicate, thus leaving to the emperor in the East sole imperial authority. In any case, the changeover was gradual and by 330, when Constantine the Great inaugurated his new capital, the process of Hellenization and Christianization was underway. The name Byzantine Empire is a modern term, introduced in 1557 by German historian Hieronymus Wolf, as being Byzantium was the ancient Greek name for the Eastern Roman capital of Constantinople.
Throughout its existence the Byzantine Empire was subject to important changes in its boundaries. The core of the empire consisted of the Balkan Peninsula (i.e., Thrace, Macedonia, Epirus, Greece proper, the Greek isles, and Illyria) and of Asia Minor (present-day Turkey).
The characteristic Eastern influence began with Constantine I, who also introduced Christianity. Orthodoxy triumphed over Arianism under Arcadius' predecessor, Theodosius I, but violent religious controversy was chronic. The reigns (395-527) of Arcadius, Theodosius II, Marcian, Leo I, Leo II, Zeno, Anastasius I, and Justin I were marked by the invasions of the Visigoths under Alaric I, of the Huns of Attila, and of the Avars, the Slavs, the Bulgars, and the Persians. After the Western Empire fell (476) to Odoacer, Italy, Gaul, and Spain were theoretically united under Zeno but were actually dominated by, respectively, the Ostrogoths, the Franks, and the Visigoths, while Africa was under the Vandals. During this period arose the heresies of Nestorianism and Monophysitism and the political parties of Blues and Greens to divide the Byzantines.
Under Justinian (527-565), and the brilliant general Belisarius, the empire temporarily regained some of the lost Roman provinces in the west, conquering much of Italy, north Africa, and Spain. Head of the administration in Italy (with Ravenna as capital) and Africa (with Cartage as capital) was an exarch, with political and military power. Justinian updated the ancient Roman legal code in the new Corpus Juris Civilis, although it is notable that these laws were still written in Latin, a language which was becoming archaic and poorly understood even by those who wrote the new code. Under Justinian's reign, the Church of Hagía Sofía (Holy Wisdom) was constructed in the 530s. This church would become the centre of Byzantine religious life and the centre of the Eastern Orthodox form of Christianity.

Justinian left his successors an empty treasury, however, and they were unable to deal with the sudden appearance of new invaders on all fronts. The Lombards conquered most of Italy; however, the Pentapolis (Rimini, Ancona, Fano, Pesaro, and Senigallia), Rome, Sardinia, Corsica, Liguria, and the coasts of South Italy and Sicily long remained under Byzantine rule, and at Ravenna the exarchs governed until 751.
The Avars and later the Bulgars overwhelmed much of the Balkans, and in the early 7th century the Persians invaded and conquered Egypt, Palestine, Syria and Armenia. The Persians were defeated and the territories were recovered by the emperor Heraclius in 627, but the unexpected appearance of the newly converted and united Muslim Arabs took by surprise an empire exhausted by the titanic effort against Persia, and the southern provinces were all overrun. Mesopotamia, Syria, Egypt, and the Exarchate of Africa were permanently incorporated into the Muslim Empire in the 7th century, a process which was completed with the fall of Carthage to the Caliphate in 698.
The Lombards continued to expand in northern Italy, taking Ligura in 640 and conquering most of the Exarchate of Ravenna in 751, leaving the Byzantines with control only of small areas inSouth Italy.
Heraclius fully Hellenized the empire by making Greek language the official one, thus ending the last remnants of Latin and ancient Roman tradition within the Empire. The empire was also by now noticeably different in religion from the former imperial lands in western Europe, although the southern Byzantine provinces differed significantly from the north in culture and practiced Monophysite (rather than Chalcedonian Orthodox) Christianity. The loss of the southern provinces to the Arabs made Orthodoxy stronger in the remaining provinces. Constans II (641 - 668) divided the empire into a system of military provinces called thémata (themes) to face permanent assault, with urban life declining outside the capital while Constantinople grew to become the largest city in the Christian world.
In 678 the attempt by the Arabs to conquer Constantinople failed in the face of the Byzantines' superior navy and the skill of warrior emperors such as Leo III the Isaurian (717 - 741), who defeated the Arabs at Akròinos in 739, meanwhile in 733 the Francs under Charles Martello stopped the Western Arab expansion in the battle of Poitiers.
After the siege of 717 in which the Arabs suffered horrific casualties, the Caliphate was never a serious threat to the Byzantine heartland. It would take a different civilization, that of the Seljuk Turks, to finally drive the imperial forces out of eastern and central Anatolia.
Thanks to the efforts of Empress Irene, the Second Council of Nicaea met in 787 and affirmed that icons could be venerated but not worshipped. The grave issue of iconoclasm, which they precipitated, led to the loss of Rome. In 800, during the reign of Irene, the Frank Charlemagne was crowned emperor of the West at Rome. Thus ended even the theoretical primacy of Byzantium over Europe. Nicephorus I (802-811) opposed his Empire to the Holy Roman Empire, but in 812 a treaty was signed with Charlemagne, leaving to the Franks the Exarchate: Venice started in this period its growth as an independent marine power. The iconoclast controversy returned in the early 9th century, but was resolved once more in 843. These controversies did not help the disintegrating relations with the Roman Catholic Church and the Holy Roman Empire, which were both beginning to gain more power of their own.
The empire reached its height under the Macedonian emperors of the late 9th, 10th and early 11th centuries. During these years the Empire held out against pressure from the Roman church to remove Patriarch Photios, and gained control over the Adriatic Sea, parts of Italy, and much of the land held by the Bulgarians. The Bulgarians were completely defeated by Basil II (976 - 1025) in 1014. Whit Basil II, the Empire gained its maximum extension.
In 1054 relations between Greek-speaking Eastern and Latin-speaking Western traditions within the Christian Church reached a terminal crisis. There was never a formal declaration of institutional separation, and the so-called Great Schism actually was the culmination of centuries of gradual separation. From this split, the modern (Roman) Catholic and Eastern Orthodox churches arose. The Byzantine Empire lost its claim to universality, becoming a Greek monarchy
Like Rome before it, though, Byzantium soon fell into a period of difficulties, caused to a large extent by the growth of the landed aristocracy, which undermined the theme system. Facing its old enemies, the Holy Roman Empire and the Abbasid caliphate, it might have recovered, but around the same time new invaders appeared on the scene who had little reason to respect its reputation. The Normans finally completed the Byzantine expulsion from Italy in 1071, and the Seljuk Turks, who were mainly interested in defeating Egypt under the Fatimids, still made moves into Asia Minor, the main recruiting ground for the Byzantine armies. With the defeat at Manzikert of emperor Romanus IV in 1071 by Alp Arslan, sultan of the Seljuk Turks, most of that province was lost.
A partial recovery was made possible after Manzikert by the rise to power of the Comnenian dynasty. The first emperor of this line, Alexius Comnenus, whose life and policies would be described by his daughter Anna in The Alexeid, began to reestablish the army on the basis of feudal grants and made significant advances against the Seljuk Turks. His plea for western aid against the Seljuk advance brought about the First Crusade, which helped him reclaim Nicaea but soon distanced itself from imperial aid. Later crusades grew increasingly antagonistic. Although Alexius' grandson Manuel I Comnenus was a friend of the Crusaders, neither side could forget that the other had excommunicated them, and the Byzantines were very suspicious of the intentions of the Roman Catholic Crusaders who continually passed through their territory.
The Germans of the Holy Roman Empire and the Normans of Sicily and Italy continued to attack the empire in the 11th and 12th centuries. The Italian city states, who had been granted trading rights in Constantinople by Alexius, became the targets of anti-Western sentiments as the most visible example of Western "Franks" or "Latins." The Venetians were especially disliked, even though their ships were the basis of the Byzantine navy. To add to the empire's concerns, the Seljuks remained a threat, defeating Manuel at Myriokephalon in 1176.
Frederick Barbarossa attempted to conquer the empire during the Third Crusade, but it was the Fourth Crusade that had the most devastating effect on the empire. Although the intent of the crusade was to conquer Egypt, the Venetians took control of the expedition, and under their influence the crusade captured Constantinople in 1204. As a result a short-lived feudal kingdom was founded (the Latin Empire), and Byzantine power was permanently weakened. At this time the Serbian Kingdom under the Nemanjic dynasty grew stronger with the collapse of Byzantium, forming a Serbian Empire in 1346.
Three Byzantine successor states were left - the Empire of Nicaea, the Empire of Trebizond, and the Despotate of Epirus. The first, controlled by the Palaeologan dynasty, managed to reclaim Constantinople in 1261 and defeat Epirus, reviving the empire but giving too much attention to Europe when the Asian provinces were the primary concern. For a while the empire survived simply because the Muslims were too divided to attack, but eventually the Ottomans overran all but a handful of port cities.
The empire appealed to the west for help, but they would only consider sending aid in return for reuniting the churches. Church unity was considered, and occasionally accomplished by law, but the Orthodox citizens would not accept Roman Catholicism. Some western mercenaries arrived to help, but many preferred to let the empire die, and did nothing as the Ottomans picked apart the remaining territories.
Constantinople was initially not considered worth the effort of conquest, but with the advent of cannons, the walls, which had been impenetrable except by the Crusaders for over 1000 years, no longer offered adequate protection from the Ottomans. The Fall of Constantinople finally came after a two-month siege by Mehmed II on May 29, 1453. The last Byzantine emperor, Constantine X Paleologus died fighting the Turks on the ramparts of Constantinople. Mehmed II also conquered Mistra in 1460 and Trebizond in 1461. Mehmed styled himself the proper successor to the Eastern Roman Emperors and by the end of the century the Ottoman Empire had established its firm rule over Asia Minor and most of the Balkan peninsula.